Isotope Standards
Medchemexpress LLC Imatinib-d4 | 1134803-16-9 | 99.9% | 497.63 | C29H27D4N7O | 10 MG
Imatinib-d4 is a deuterium-labeled analogue of imatinib provided for research use as a stable isotope internal standard. It is intended for bioanalytical and pharmacokinetic applications where mass-shifted quantification improves accuracy and precision in LC-MS assays and metabolic studies.
- Stable isotope labeled internal standard for LC-MS assays.
- Four deuterium atoms create a clear mass shift for quantification.
- High chemical purity for consistent analytical performance.
- Suitable for pharmacokinetic, bioanalytical, and metabolic studies.
- Available in small milligram quantities for laboratory use.
Medchemexpress LLC DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 100 MG
DC-LC3in-D5 is an autophagy inhibitor that attenuates LC3B lipidation by binding with LC3B and disrupting the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound demonstrates high selectivity to LC3A/B in the proteome and exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells. It may contribute to anti-HCV or combination research in cancer through inhibiting autophagy.
- Acts as an autophagy inhibitor by attenuating LC3B lipidation
- Binds with LC3B and disrupts the LC3B-LBP2 interaction
- Demonstrates high selectivity to LC3A/B in the proteome
- Exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells
- Treatment of HeLa cells with 3-30 μM results in disruption of LC3B lipidation, inhibition of autophagic vesicle formation, and accumulation of p62
Medchemexpress LLC DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 50 MG
DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 50 MG
Cambridge Isotope Laboratories 11-DEOXYCORTISOL (2,2,4,6,6-D5, 98%) 100 UG/ML IN METHANOL, 1 ML, 1258063-56-7
11-DEOXYCORTISOL (2,2,4,6,6-D5, 98%) 100 UG/ML IN METHANOL, 1 ML, 1258063-56-7
Medchemexpress LLC Enalaprilat-d5 | 349554-00-3 | 99.5% | 10 MG
Enalaprilat-d5 is a deuterium-labeled analogue of enalaprilat used as a reference standard in biochemical and pharmacokinetic research. It acts as an angiotensin-converting enzyme (ACE) inhibitor and is provided as a high-purity analytical standard for assay development and quantitation.
- Deuterium-labeled internal standard for analytical assays.
- High isotopic enrichment and 99.5% purity for reliable quantitation.
- Suitable for LC-MS/MS method development and validation.
- Available in small pack sizes (for example, 10 mg) for bench-scale work.
- Supplied as a dry powder for convenient dissolution and storage.
Medchemexpress LLC Abt-737-d8 | 1217686-68-4 | 99.1% | C42H37D8ClN6O5S2 | 5 MG
ABT-737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. It induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 also induces autophagy and has the potential for acute myeloid leukemia (AML) research.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Alendronic acid-d6 | 1035437-39-8 | 98.0% | 255.13 | C4H7D6NO7P2 | 10 MG
Alendronic acid-d6 is the deuterium-labeled analogue of alendronic acid supplied as a solid stable-isotope reagent for use as a tracer and internal standard in quantitative analytical methods such as NMR, GC-MS, and LC-MS. Purity 98.0%; molecular weight 255.13; molecular formula C4H7D6NO7P2. Storage: powder at -20°C (up to 3 years) or 4°C (up to 2 years); in solvent at -80°C (up to 6 months).
- Deuterium-labeled internal standard for quantitative NMR, GC-MS, and LC-MS.
- High purity (98.0%) suitable for analytical workflows.
- Solid powder form with defined long-term storage conditions.
- Provides molecular weight and structural information for method development.
- Available in small pack sizes for tracer and reference applications.
Medchemexpress LLC ABT-737-d8 | 1217686-68-4 | 99.1% | C42H37D8ClN6O5S2 | 100 UG
ABT-737-d8 is the deuterium labeled ABT-737, a BH3 mimetic and a potent inhibitor of Bcl-2, Bcl-xL, and Bcl-w. It induces the disruption of the BCL-2/BAX complex and BAK-dependent, BIM-independent activation of the intrinsic apoptotic pathway, and also induces autophagy.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Has potential for acute myeloid leukemia (AML) research
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development
- Deuteration can affect the pharmacokinetic and metabolic profiles of drugs
- For research use only
Cambridge Isotope Laboratories 5,6-DIHYDROURACIL (13C4, 99%; 15N, 98%+), 25 MG
5,6-DIHYDROURACIL (13C4, 99%; 15N, 98%+), 25 MG